In the oral study, positive linear trends were observed in the incidence of follicular cell adenomas and carcinomas in the thyroid glands of female rats, and in the incidence of benign and malignant pheochromocytomas in the adrenal medullas of male rats. GALDERMA LABORATORIES, L.P. For example, if your acne is on the face, apply the product to the entire face. • Differin Gel should be stored at room temperature [68° - 77°]. Differin Gel Adapalene Gel 0.1% Acne Treatment Differin contains the first OTC Rx-strength acne-fighting retinoid. You may want to delay starting Differin Gel until any irritation from using the other product(s) has gone away.• Moisturizers may be used.• Irritation usually lessens after 4 weeks of continued use. Not For Ophthalmic Use. Differin Gel - Patient Information Leaflet (PIL) by Galderma (U.K) Ltd Medically reviewed by Drugs.com. A thin film of cream should be applied, with the fingertips, avoiding the eyes and lips (see 4.4 Special warnings and special precautions for use, below).Ensure … do not use more than one time a day. These are most likely to occur during the first two to four weeks and will usually lessen with continued use of the medication. • Apply this product only one time a day and try to apply the product at the same time each day. The gel formulation was first marketed in France in September 1995. These are most commonly seen during the first month of therapy and decrease in frequency and severity thereafter. The product should not be applied to cuts, abrasions, eczematous skin, or sunburned skin. If contact occurs, immediately flush the area with water. (Tretinoin is also the key ingredient in a number of other brand name retinoids, such as ReFissa and Renova.) GALDERMA LABORATORIES, L.P. Baie d’Urfé, QC, H9X 3S4 Canada Differin Cream 0.1% and Differin Gel 0.1% are 2 formulations with the same active ingredient, adapalene. Marketed by: Frequently Asked Questions (Continued). Animal studies have shown an increased tumorigenic risk with the use of pharmacologically similar drugs (e.g., retinoids) when exposed to UV irradiation in the laboratory or to sunlight. May contain hydrochloric acid to adjust pH. It’s the first new OTC active ingredient to treat acne approved by the FDA in more than 30 years. After using for the time stated, my chin feels smoother and I need less foundation and concealer. Both Differin gel and cream contain the same concentration (0.1%) of the active ingredient adapalene.Hence its efficacy/effectiveness is similar. Drugs.com provides accurate and independent information on more than 24,000 prescription drugs, over-the-counter medicines and natural products. How should I store this product? Avoid products containing alpha hydroxyl or glycolic acids which may worsen irritation. Only trace amounts (<0.25 ng/mL) of parent substance have been found in the plasma of acne patients following chronic topical application of adapalene in controlled clinical trials. The other ingredients are: carbomer 940, edetate disodium, methylparaben, poloxamer 182, propylene glycol, purified water, and sodium hydroxide. by: May contain hydrochloric acid to adjust pH. The gel form dries quicker and may be preferred in acne patients with oily skin.. limit sun exposure, including light from tanning beds, and use sunscreen when going outdoors, do not wax to remove hair in areas where the product has been applied, during the early weeks of use, your acne may appear to worsen before it improves (this is normal); continue using as directed, unless you get irritation that becomes severe. P50045-1 Patients with sunburn should be advised not to use the product until fully recovered. We comply with the HONcode standard for trustworthy health information -. Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances. • If irritation becomes severe (overly bothersome), stop use and ask a doctor before using the product again. Each gram contains: adapalene 0.1% (1 mg) in a vehicle consisting of carbomer 940, edetate disodium, methylparaben, poloxamer 182, propylene glycol, purified water, and sodium hydroxide. For External Use Only. Retinoids play a crucial role in the treatment of acne by regulating skin cell turnover & reducing inflammation deep in the skin to clear & prevent pimples. Use of sunscreen products and protective clothing over treated areas is recommended when exposure cannot be avoided. If Differin (adapalene) is swallowed, call a doctor or poison control center right away. Adapalene 0.1% (retinoid)**read consumer information leaflet. Store at controlled room temperature 68° to 77°F (20°-25°C) with excursions permitted between 59° - 86°F (15°-30°C). Protect from freezing.• Do not use the product after the expiry date marked on the packaging. Ingredients Present In Differin Gel. Due to the many side effects of the drug, it is available only through prescription. • Differin Gel should be stored at room temperature [68° - 77°]. Patients who normally experience high levels of sun exposure, and those with inherent sensitivity to sun, should be warned to exercise caution. Usual dosage: Apply a thin film once a day to affected areas after washing in the evening before retiring. Applying more than directed will not provide faster or better results, but may worsen skin irritation. Available for Android and iOS devices. Because many drugs are excreted in human milk, caution should be exercised when Differin Gel is administered to a nursing woman. The other ingredients are: carbomer 940, edetate disodium, methylparaben, poloxamer 182, propylene glycol, purified water, and sodium hydroxide. Safety and effectiveness in pediatric patients below the age of 12 have not been established. DIFFERIN ® Gel, containing adapalene, is used for the topical treatment of acne vulgaris. DIFFERIN (adapalene gel) Gel, 0.1% is supplied in the following size: Store at controlled room temperature 68° - 77°F (20° - 25°C), excursions permitted between 59° and 86°F (15° - 30°C). The acute oral toxicity of Differin Gel in mice and rats is greater than 10 mL/kg. Depending upon the severity of adverse events, patients should be instructed to reduce the frequency of application or discontinue use. • Gently clean the affected areas using a mild (non-irritating) cleanser and pat dry.• Apply Differin Gel as a thin layer to the affected areas of the skin only one time a day. cover the entire affected area with a thin layer. Other Questions? •Yes, use of a moisturizer may help decrease dryness and other signs of irritation. Although the exact mode of action of adapalene is unknown, it is suggested that topical adapalene may normalize the differentiation of follicular epithelial cells resulting in decreased microcomedone formation. The postmarketing data detailed below refer to reports collected from the worldwide sales with the gel formulation. Therapeutic results should be noticed after eight to twelve weeks of treatment. Differin Soothing Moisturizer is compatible for use with Differin Gel to alleviate dryness while leaving [more] [more] your skin soft and smooth. DIFFERIN GEL Inactive ingredients: carbomer 940, edetate disodium, methylparaben, poloxamer 124, propylene glycol, purified water and sodium hydroxide. • When possible, limit sun exposure, including light from tanning beds. In a series of in vivo and in vitro studies, adapalene did not exhibit mutagenic or genotoxic activities. Non-comedogenic, fragrance-free Differin Gel contains the retinoid adapalene, the first over-the-counter active ingredient for acne in more than 30 years. DIFFERIN (adapalene) Gel, 0.3% contains adapalene 0.3% (3 mg/g) in a topical aqueous gel for use in the treatment of acne vulgaris, consisting of carbomer 940, edetate disodium, methylparaben, poloxamer 124, propylene glycol, purified water, and sodium hydroxide. Galderma Differin Adapalene Gel ingredients explained: Adapalene (0.1%), Carbomer, Propylene Glycol, Poloxamer 182, Disodium Edetate, Methyl Parahydroxybenzoate (0.1%), Phenoxyethanol (0.25%), Sodium Hydroxide, Purified Water Differin Gel (adapalene 0.1%) has the power of a prescription, yet it is the first topical retinoid available over the counter to fight acne. Side effects requiring immediate medical attention. Each gram of Differin Gel contains adapalene 0.1% (1 mg) in a vehicle consisting of carbomer 940, edetate disodium, methylparaben, poloxamer 182, propylene glycol, purified water and sodium hydroxide. Differin Gel consists of Adapalene as the key ingredient. We comply with the HONcode standard for trustworthy health information -, on damaged skin (cuts, abrasions, eczema, sunburn). Children under 12 years of age: ask a doctor. Active ingredient: adapalene. Last updated on May 22, 2020. See carton closure for lot number and expiration date. Most of my acne issues were on my skin, and it has a pebbled feel/appearance. Differin Gel is intended for cutaneous use only. • When going outdoors, use a sunscreen as labeled. DIFFERIN® Gel, containing adapalene, is used for the topical treatment of acne vulgaris. Weather extremes, such as wind or cold, also may be irritating to patients under treatment with adapalene. Other Questions? G Production Inc. Biochemical and pharmacological profile studies have demonstrated that adapalene is a modulator of cellular differentiation, keratinization, and inflammatory processes all of which represent important features in the pathology of acne vulgaris. Can I use a moisturizer if my skin is dry? if you are allergic to adapalene or any of the ingredients in this product. For External Use Only. This chemical has been used in treating acne for many years now. Ingredients Take a different approach to clearing—and preventing—your acne. Mfd. Do not give Differin (adapalene) to a child younger than 12 years old without first checking with the doctor. There are no adequate and well-controlled studies in pregnant women. carbomer 940, edetate disodium, methylparaben, poloxamer 182,propylene glycol, purified water and sodium hydroxide.May contain hydrochloric acid to adjust pH.